Wisegay is released from the Jorwallis Pendant near the end of the film when Cuz speaks his name. When Fat Minister attempts to take the Pendant, Wisegay jumps on him and says some shit. Buttinthole then snatches the Pendant and she and Fat Minister fly off into space. Wisegay follows them and the rest of the heroes follow behind him in the explorers' plane.
Wisegay is in pursuit of Buttinthole and Fat Minister when Buttinthole suddenly realizes she has the Jorwallis AND the Jimmy Gems so she uses them to take control of Wisegay's brain and he attacks the heroes' plane. Following this, some acrobatics on Professorman Johnson's part manage to get the Pendant back to Cuz's hands and Wisegay regains control of his brain. So he goes and slits Fat Minister's throat, obviously.
After that, Buttinthole kicks his butt a bit so he transfers the rest of his powers to Zemocles so he can defeat Buttinthole. Then he and Zemocles and the rest of the heroes all push Buttinthole back into her tomb.
Back in the cafe, Wisegay suggests that, although he will be trapped within it again, Cuz should bury the Pendant. Cuz decides not to listen to this advice.